As it is known that the introduction of cyclic amino acids could cause significant changes in peptide conformation ensistance chemical and biological properties in peptides would be affected. 环状氨基酸的引入可以增加结构的刚性,限制构象而产生不同的结构或生物效应。
The synthesis and applications of cyclic peptide compounds were discussed in this article. 介绍了近年来环三肽化合物的合成方法及应用的进展情况。
Objective To prepare polyclonal anti-LPS antibody with cross protection against LPS from different bacteria and to screen mimotopes of LPS from cyclic 7-mer phage peptide library. 目的获得具交叉保护性的抗细菌脂多糖(LPS)多克隆抗体与模拟LPS多表位的噬菌体展示环肽克隆。
Methods An artificial RGD-containing cyclic peptide was labeled with fluorescein isothiocyanate ( FITC). 方法采用异硫氢酸荧光素(FITC)标记环八肽(FITC-cRGD);
Gramicidin S is the most thoroughly studied cyclic peptide since now, its mechanism is destorying the structure of the membrane, inducing the leakage of the endocellular materials, and killing the microbial cells at last. 短杆菌肽S是迄今为止研究得最详细的一种与细胞膜发生相互作用的环状肽类抗生素.它的作用机理是破坏细胞膜结构,导致细胞内含物的释放,而最终引起细胞的死亡。
Cyclic dipeptides are the simplest members in the most common cyclic peptide family found in nature. 而环二肽是环肽成员中最小的一类化合物,在自然界中普遍存在。
According to the results of EST analysis of Chaetomium globosum, a cyclic peptide HC-toxin gene of clone was selected from the cDNA library, and then sequenced and analyzed it. 根据EST分析的结果,从cDNA文库中挑取循环肽HC-毒素基因的克隆进行了测序并序列分析。
Diagnostic values of sera antibodies to cyclic citrullinated peptide in patients with hepatitis C virus infection complicated with mixed cryoglobulinemia 血清ACCP在HCV感染并发冷球蛋白血症的诊断价值
Amanitin and phalloidin are cyclic peptide toxins composed of some modified amino acids distributing mainly in poisonous Amanita mushroom. -鹅膏毒(环)肽和二羟鬼笔毒(环)肽是剧毒的鹅膏菌和其它几种致死毒菌中由一些修饰氨基酸组成的环肽毒素。
Research of electrochemical impedance spectroscopy on self-assembling cyclic peptide membrane bonded Ca~ ( 2+) supported by gold 络合Ca~(2+)的Au/巯基环肽自组装单层膜的交流阻抗研究
Sequence Analysis for Cyclic Peptide HC-toxin Gene of Chaetomium globosum 球毛壳菌循环肽HC-毒素基因的序列分析
The cyclic lipopeptides are consequently divided into three types according to the connecting ways of fat acid chains and peptide chains. 按脂肪酸链和肽链的连接方式不同,进一步将环状脂肽分为3类。
Objective To investigate the diagnostic values of sera antibodies to cyclic citrullinated peptide ( ACCP) in patients with hepatitis C virus ( HCV) infection complicated with mixed cryoglobulinemia ( MC). 目的探讨血清抗环瓜氨酸肽抗体(ACCP)在丙型肝炎病毒(HCV)感染并发冷球蛋白血症中的诊断价值。
Objective To investigate the binding characteristics between an artificial Arg-Gly-Asp ( RGD)-containing cyclic peptide [ cyclo ( CGRGDSPK)] and rat hepatic stellate cells ( HSC). 目的探讨人工合成的含有精-甘-天冬氨酸(Arg-Gly-Asp,RGD)序列的环八肽(cRGD)与大鼠肝星状细胞(HSC)体外的结合特点。
This paper also introduces the selection for the classification of the cyclic peptide, cyclization sites, the choice of the cyclization reagents, liquid phase synthesis of cyclic peptides and solid-phase synthesis, and the nature of cyclic peptide. 本文还对环肽的分类、环合位点的选取、环合试剂的选择、环肽的液相合成和固相合成研究进展进行了介绍,并对环肽的性质进行了简介。
The ten-and twelve-residue cyclic peptide was hard to self-assemble, and the self-assembling of twelve-residue cyclic peptide had to consider the conformation of ring, the symmetry of ring conformation as well as the stability of side chain. 环十肽及环十二肽的自组装较难进行,要考虑环肽的空间构象、构象的对称性以及侧链等因素对自组装的影响。